Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | VEGFA | P15692 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875607 | 1.00 | AR (0.52) | ARCYP11B1CYP11B2SCN9AVEGFA | |
| SCHEMBL875413 | 0.91 | AR (0.43) | ARCYP11B1CYP11B2SCN9AVEGFA | |
| SCHEMBL24385793 | 0.85 | CYP11B1 (0.41) | ARCYP11B1CYP11B2SCN9AVEGFA | |
| SCHEMBL14670094 | 0.84 | AR (0.46) | ARCYP11B1CYP11B2SCN9AVEGFA | |
| SCHEMBL29918418 | 0.84 | AR (0.60) | ARSCN9A | |
| SCHEMBL14656415 | 0.84 | AR (0.60) | ARSCN9A | |
| SCHEMBL29769048 | 0.83 | AR (0.57) | ARSCN9AEPAS1SMN1; SMN2 | |
| SCHEMBL875321 | 0.83 | AR (0.57) | ARSCN9AEPAS1SMN1; SMN2 | |
| SCHEMBL875025 | 0.83 | SLC22A12 (0.47) | ARCYP11B1CYP11B2VEGFAEPAS1 | |
| SCHEMBL14661984 | 0.83 | TLR8 (0.40) | AREPAS1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239135-B1 | PYRIMIDONE COMPOUNDS USED AS LP-PLA2 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2022-05-04 | — | — | EP | disclosed |