Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 8/20 | 0.46 |
| ▸ | F2 | P00734 | 5/20 | 0.44 |
| ▸ | PLAU | P00749 | 5/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 5/20 | 0.44 |
| ▸ | CNR2 | P34972 | 4/20 | 0.42 |
| ▸ | CNR1 | P21554 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23783187 | 1.00 | ELANE (0.46) | ELANEF2PLAUCTRB1CNR2 | |
| SCHEMBL25444558 | 0.88 | CNR2 (0.42) | ELANEF2PLAUCTRB1CNR2 | |
| SCHEMBL23782916 | 0.85 | ELANE (0.43) | ELANEF2PLAUCTRB1CNR2 | |
| SCHEMBL4007969 | 0.85 | ELANE (0.45) | ELANEF2PLAUCTRB1CNR2 | |
| SCHEMBL23782945 | 0.83 | ELANE (0.41) | ELANEMAPTLMNAALDH1A1 | |
| SCHEMBL22445983 | 0.82 | ELANE (0.41) | ELANEF2PLAUCTRB1CNR2 | |
| SCHEMBL29643935 | 0.80 | CNR2 (0.42) | ELANEF2PLAUCTRB1CNR2 | |
| SCHEMBL3517132 | 0.80 | ELANE (0.41) | ELANEF2PLAUCTRB1CNR2 | |
| SCHEMBL2470918 | 0.79 | CNR2 (0.45) | ELANEF2PLAUCTRB1CNR2 | |
| SCHEMBL3517141 | 0.79 | CNR2 (0.45) | ELANEF2PLAUCTRB1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3997081-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | Escape Bio, Inc. (US) | 2022-05-18 | — | — | EP | disclosed |