Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bi-2536. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 known ✓ | P53350 | 12/20 | 0.99 |
| ▸ | BRD4 | O60885 | 15/20 | 0.99 |
| ▸ | PLK3 | Q9H4B4 | 6/20 | 0.99 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.99 |
| ▸ | TAF1 | P21675 | 5/20 | 0.99 |
| ▸ | PLK2 | Q9NYY3 | 4/20 | 0.99 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.99 |
| ▸ | CLK2 | P49760 | 3/20 | 0.99 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.99 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.99 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.99 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.99 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.99 |
| ▸ | CSNK1G3 | Q9Y6M4 | 3/20 | 0.99 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.99 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.99 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.99 |
| ▸ | EGFR | P00533 | 2/20 | 0.99 |
| ▸ | FES | P07332 | 2/20 | 0.99 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.99 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bi-2536 SCHEMBL16984416 | 0.99 | BRD4 (1.00) | BRD4PLK1PLK3ALKTAF1 | |
| Bi-2536 SCHEMBL372489 | 0.99 | BRD4 (1.00) | BRD4PLK1PLK3ALKTAF1 | |
| Bi-2536 SCHEMBL614114 | 0.99 | BRD4 (1.00) | BRD4PLK1PLK3ALKTAF1 | |
| Bi-2536 SCHEMBL29395966 | 0.99 | BRD4 (1.00) | BRD4PLK1PLK3ALKTAF1 | |
| SCHEMBL13227794 | 0.95 | BRD4 (0.92) | BRD4PLK1PLK3ALKTAF1 | |
| SCHEMBL24851804 | 0.95 | PLK1 (1.00) | BRD4PLK1PLK3ALKTAF1 | |
| SCHEMBL4515444 | 0.94 | BRD4 (1.00) | BRD4PLK1PLK3ALKTAF1 | |
| SCHEMBL16972068 | 0.93 | BRD4 (1.00) | BRD4PLK1PLK3ALKTAF1 | |
| SCHEMBL16972069 | 0.93 | BRD4 (1.00) | BRD4PLK1PLK3ALKTAF1 | |
| SCHEMBL376236 | 0.93 | PLK1 (0.89) | BRD4PLK1PLK3ALKTAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240034799-A1 | METHODS AND SYSTEMS OF STRATIFYING INFLAMMATORY DISEASE PATIENTS | CEDARS SINAI MEDICAL CENTER (US) | 2024-02-01 | — | — | US | disclosed |
| EP-4256086-A1 | METHODS AND SYSTEMS OF STRATIFYING INFLAMMATORY DISEASE PATIENTS | Cedars-Sinai Medical Center (US) | 2023-10-11 | — | — | EP | disclosed |
| US-20230279491-A1 | TREATMENTS FOR A SUB-POPULATION OF INFLAMMATORY BOWEL DISEASE PATIENTS | CEDARS-SINAI MEDICAL CENTER | 2023-09-07 | — | — | US | disclosed |
| EP-4162076-A1 | TREATMENTS FOR A SUB-POPULATION OF INFLAMMATORY BOWEL DISEASE PATIENTS | Cedars-Sinai Medical Center (US) | 2023-04-12 | — | — | EP | disclosed |
| WO-2022119842-A1 | METHODS AND SYSTEMS OF STRATIFYING INFLAMMATORY DISEASE PATIENTS | CEDARS-SINAI MEDICAL CENTER (US) | 2022-06-09 | — | — | WO | disclosed |