SCHEMBL29645129

SCHEMBL29645129

CN(C)Cc1ccc2c(Cl)cc(Cl)cc2n1

nearest known ligand 0.45

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 1/20 0.45
HRH3 Q9Y5N1 1/20 0.39
POLB P06746 1/20 0.37
NOTUM Q6P988 1/20 0.36
FERMT2 Q96AC1 1/20 0.35
MCHR1 Q99705 1/20 0.35
NR4A2 P43354 1/20 0.35
SLC6A2 P23975 2/20 0.33
SLC6A4 P31645 2/20 0.33
SLC6A3 Q01959 2/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7813478 0.78 S1PR4 (0.45) PDE10AHRH3POLBNOTUMNR4A2
SCHEMBL13727935 0.73 MAPT (0.41) NOTUMMAPT
SCHEMBL29350457 0.72 MAPT (0.58) NOTUMSLC6A2MAPT
SCHEMBL8342589 0.72 MAPT (0.58) NOTUMSLC6A2MAPT
SCHEMBL5258862 0.72 POLB (0.56) PDE10AHRH3POLBNR4A2MAPT
SCHEMBL3972257 0.71 HRH3 (0.46) PDE10AHRH3POLBNR4A2MAPT
Hydrochloric Acid SCHEMBL3819659 0.71 MAPT (0.56) SLC6A2MAPT
Hydrochloric Acid SCHEMBL30824020 0.71 MAPT (0.56) SLC6A2MAPT
SCHEMBL28829501 0.69 HRH3 (0.42) PDE10AHRH3POLBNR4A2MAPT
SCHEMBL10027258 0.69 KDM4E (0.48) NOTUMSLC6A2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12281362-B2 Diagnostic tools and treatments for clear cell renal cell carcinoma UNIVERSITY OF CINCINNATI (US) 2025-04-22 US disclosed
US-20220136059-A1 Diagnostic Tools and Treatments for Clear Cell Renal Cell Carcinoma UNIVERSITY OF CINCINNATI (US) 2022-05-05 US disclosed