Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.75 |
| ▸ | CASP1 | P29466 | 1/20 | 0.75 |
| ▸ | CASP7 | P55210 | 1/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | POLR1A | O95602 | 16/20 | 0.65 |
| ▸ | ECE1 | P42892 | 1/20 | 0.62 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17099654 | 1.00 | KDM4E (0.75) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL25761771 | 0.88 | POLR1A (0.67) | KDM4EMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL17117513 | 0.88 | POLR1A (0.64) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL18631335 | 0.86 | KDM4E (1.00) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL21798989 | 0.84 | KDM4E (0.71) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL29649777 | 0.84 | KDM4E (0.71) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL21798961 | 0.84 | KDM4E (0.71) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL21798898 | 0.83 | KDM4E (0.69) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL21798922 | 0.83 | KDM4E (0.69) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL21798938 | 0.83 | KDM4E (0.69) | KDM4ECASP1CASP7HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022060816-A1 | COMPOUNDS WHICH INHIBIT RNA POLYMERASE | THE JOHNS HOPKINS UNIVERSITY (US) | 2022-03-24 | — | — | WO | disclosed |