Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.50 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27920449 | 0.88 | EGFR (0.50) | EGFRBAZ1ACSNK2A2CSNK2BMGLL | |
| SCHEMBL2051696 | 0.84 | EGFR (0.56) | EGFRIMPDH2BAZ1ACSNK2A2CSNK2B | |
| SCHEMBL29648012 | 0.81 | EGFR (0.50) | EGFRIMPDH2BAZ1ACSNK2A2CSNK2B | |
| SCHEMBL12466410 | 0.79 | EGFR (0.53) | EGFRIMPDH2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL30533141 | 0.79 | EGFR (0.53) | EGFRIMPDH2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL28063529 | 0.78 | EGFR (0.49) | EGFRIMPDH2BAZ1ACSNK2A2CSNK2B | |
| SCHEMBL29648047 | 0.78 | HPGD (0.34) | CSNK2A2CSNK2BHPGDSCSNK2A1 | |
| SCHEMBL24054680 | 0.78 | EGFR (0.51) | EGFRIMPDH2BAZ1ANOTUMPRMT3 | |
| SCHEMBL28850937 | 0.78 | EGFR (0.51) | EGFRIMPDH2BAZ1ACSNK2A2CSNK2B | |
| SCHEMBL1105475 | 0.78 | EGFR (0.51) | EGFRIMPDH2BAZ1ANOTUMPRMT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3999498-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | Kinnate Biopharma Inc. (US) | 2022-05-25 | — | — | EP | disclosed |