Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.35 |
| ▸ | SPR | P35270 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1371388 | 0.98 | CA1 (0.56) | CA1CA2CYP2D6SMN1; SMN2CYP2C19 | |
| SCHEMBL29649313 | 0.95 | CA1 (0.52) | CA1CA2CYP2D6SMN1; SMN2CYP2C19 | |
| SCHEMBL22404281 | 0.90 | CA1 (0.50) | CA1CA2CYP2D6SMN1; SMN2CYP2C19 | |
| SCHEMBL347200 | 0.80 | CYP2D6 (0.37) | CYP2D6SMN1; SMN2CYP2C19TSHRCYP2C9 | |
| SCHEMBL19534267 | 0.79 | CA1 (0.41) | CA1CA2CYP2D6SMN1; SMN2CYP2C19 | |
| SCHEMBL8225935 | 0.78 | TSHR (0.38) | CA1CA2CYP2D6SMN1; SMN2CYP2C19 | |
| SCHEMBL24694571 | 0.76 | CA1 (0.42) | CA1CA2CYP2D6SMN1; SMN2TSHR | |
| SCHEMBL15503069 | 0.76 | CYP2D6 (0.56) | CYP2D6SMN1; SMN2CYP2C19TSHRCYP2C9 | |
| SCHEMBL346464 | 0.76 | TSHR (0.37) | CYP2D6SMN1; SMN2CYP2C19TSHRCYP2C9 | |
| SCHEMBL8225915 | 0.76 | CYP2D6 (0.39) | CA1CA2CYP2D6SMN1; SMN2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3394068-B1 | TDO2 INHIBITORS | GENENTECH INC (US) | 2024-09-11 | — | — | EP | disclosed |
| CN-110072864-B | TDO2 inhibitors | 基因泰克公司 | 2022-05-27 | — | — | CN | disclosed |