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Sugi Predict / Compounds / SCHEMBL29650574

SCHEMBL29650574

SCHEMBL29650574

Cc1nc2cnc(N(C)C3CCN(C4CC(F)(F)C4)CC3)c(C#N)c2c(=O)n1CC#Cc1ccc(Cl)cc1-c1ccnc2c(C(=O)O)csc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ EIF4EBP1 Q13541 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22866517 1.00 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650585 0.95 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650467 0.94 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650584 0.94 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29661934 0.93 EIF4EBP1 (1.00) EIF4EBP1
Water SCHEMBL27165018 0.93 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL22866515 0.93 EIF4EBP1 (1.00) EIF4EBP1
Water SCHEMBL29885546 0.93 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650517 0.92 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650458 0.92 EIF4EBP1 (1.00) EIF4EBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4267586-A1 SOLID FORMS OF AN EIF4E INHIBITOR Pfizer Inc. (US) 2023-11-01 — — EP disclosed
WO-2022137174-A1 SOLID FORMS OF AN EIF4E INHIBITOR PFIZER INC. (US) 2022-06-30 — — WO disclosed
EP-3993875-A1 METHODS OF TREATING BRAF-MUTATED CANCER CELLS EFFECTOR THERAPEUTICS, INC. (US) 2022-05-11 — — EP disclosed
EP-3994139-A1 EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS Effector Therapeutics Inc. (US) 2022-05-11 — — EP disclosed
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