SCHEMBL29650577

SCHEMBL29650577

OCCC(O)Nc1nc(-c2ccncc2)nc2cnccc12

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LATS1 O95835 20/20 0.71
LATS2 Q9NRM7 16/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29650581 0.89 LATS1 (0.70) LATS1LATS2
SCHEMBL29650652 0.86 LATS1 (0.77) LATS1LATS2
SCHEMBL26177098 0.83 LATS1 (1.00) LATS1LATS2
SCHEMBL26177095 0.80 LATS1 (1.00) LATS1LATS2
SCHEMBL20574643 0.79 LATS1 (1.00) LATS1LATS2
SCHEMBL29650626 0.79 LATS1 (1.00) LATS1LATS2
SCHEMBL20547829 0.79 LATS1 (1.00) LATS1LATS2
SCHEMBL20547752 0.79 LATS1 (1.00) LATS1LATS2
SCHEMBL20548226 0.78 LATS1 (1.00) LATS1LATS2
SCHEMBL20547469 0.77 LATS1 (1.00) LATS1LATS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114703144-A 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors 诺华股份有限公司 2022-07-05 CN disclosed
CN-114621222-A 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors 诺华股份有限公司 2022-06-14 CN disclosed