SCHEMBL29650596

SCHEMBL29650596

CC1(Nc2nc(-c3ccnc(F)c3F)nc3cnccc23)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LATS1 O95835 20/20 1.00
LATS2 Q9NRM7 9/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26177163 1.00 LATS1 (1.00) LATS1LATS2
SCHEMBL31375901 0.81 LATS1 (1.00) LATS1LATS2
SCHEMBL20547777 0.81 LATS1 (1.00) LATS1LATS2
SCHEMBL20547803 0.80 LATS1 (1.00) LATS1LATS2
SCHEMBL20547411 0.79 LATS1 (1.00) LATS1LATS2
SCHEMBL20547852 0.79 LATS1 (1.00) LATS1LATS2
SCHEMBL31375842 0.79 LATS1 (1.00) LATS1LATS2
SCHEMBL26177114 0.78 LATS1 (1.00) LATS1LATS2
SCHEMBL20547755 0.77 LATS1 (1.00) LATS1LATS2
SCHEMBL20547902 0.76 LATS1 (1.00) LATS1LATS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114621222-A 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors 诺华股份有限公司 2022-06-14 CN claimed
CN-114621222-B 6-6 Fused bicyclic heteroaryl compounds and their use as LATS inhibitors 诺华股份有限公司 2024-12-17 CN disclosed
CN-110573511-B 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors 诺华股份有限公司 2023-04-25 CN disclosed
CN-114703144-A 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors 诺华股份有限公司 2022-07-05 CN disclosed
CN-114621222-A 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors 诺华股份有限公司 2022-06-14 CN disclosed