Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 19/20 | 0.43 |
| ▸ | LATS2 | Q9NRM7 | 17/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16908289 | 1.00 | LATS1 (0.43) | LATS1LATS2CDC7 | |
| SCHEMBL30064150 | 0.84 | CDC7 (0.47) | LATS1LATS2CDC7 | |
| SCHEMBL24746836 | 0.84 | CDC7 (0.47) | LATS1LATS2CDC7 | |
| SCHEMBL30065225 | 0.81 | LATS1 (0.59) | LATS1LATS2CDC7 | |
| SCHEMBL30064444 | 0.81 | LATS1 (0.43) | LATS1LATS2CDC7 | |
| SCHEMBL24746631 | 0.81 | LATS1 (0.43) | LATS1LATS2CDC7 | |
| SCHEMBL16908288 | 0.81 | LATS1 (0.59) | LATS1LATS2CDC7 | |
| SCHEMBL24746940 | 0.78 | LATS1 (0.44) | LATS1LATS2 | |
| SCHEMBL15645702 | 0.78 | MAPT (0.43) | LATS1LATS2 | |
| SCHEMBL15645690 | 0.77 | LATS1 (0.42) | LATS1LATS2CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114621222-B | 6-6 Fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2024-12-17 | — | — | CN | disclosed |
| EP-4347594-A1 | 2, 8-DIAZASPIRO [4.5] DECANE COMPOUNDS | Genentech, Inc. (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-117425654-A | 2, 8-diazaspiro [4.5] decane compounds | 基因泰克公司 | 2024-01-19 | — | — | CN | disclosed |
| CN-110573511-B | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2023-04-25 | — | — | CN | disclosed |
| WO-2022253341-A1 | 2, 8-DIAZASPIRO [4.5] DECANE COMPOUNDS | GENENTECH, INC. (US) | 2022-12-08 | — | — | WO | disclosed |
| CN-114703144-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-114621222-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2022-06-14 | — | — | CN | disclosed |