Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11916210 | 1.00 | JAK2 (0.44) | JAK2TYK2JAK3AURKACDC7 | |
| SCHEMBL17464105 | 0.91 | SRC (0.39) | JAK2TYK2JAK3AURKACDC7 | |
| SCHEMBL28316674 | 0.86 | CYP19A1 (0.49) | JAK2JAK3AURKADAPK3PAK4 | |
| SCHEMBL29651181 | 0.85 | PTK2 (0.50) | JAK2TYK2JAK3AURKACDC7 | |
| SCHEMBL28316669 | 0.83 | JAK2 (0.40) | JAK2JAK3AURKADAPK3PAK4 | |
| SCHEMBL17464102 | 0.83 | MKNK2 (0.48) | JAK2TYK2JAK3AURKACDC7 | |
| SCHEMBL25400261 | 0.82 | PTK2 (0.38) | JAK2TYK2JAK3AURKACDC7 | |
| SCHEMBL30219631 | 0.82 | PTK2 (0.38) | JAK2TYK2JAK3AURKACDC7 | |
| SCHEMBL26270373 | 0.79 | MAPKAPK2 (0.56) | JAK2TYK2JAK3AURKACDC7 | |
| SCHEMBL1749344 | 0.79 | PTK2 (0.64) | JAK2PTK2RPS6KA5RPS6KA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114555585-B | HPK1 inhibitors and uses thereof | 锐格药业公司 | 2025-02-11 | — | — | CN | disclosed |
| EP-3994133-A1 | HPK1 INHIBITORS AND USES THEREOF | Qilu Regor Therapeutics Inc. (CN) | 2022-05-11 | — | — | EP | disclosed |