Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 15/20 | 0.56 |
| ▸ | INSR | P06213 | 4/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.49 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22864565 | 1.00 | ALK (0.56) | ALKINSRBTKMAP4K1MET | |
| SCHEMBL29651198 | 0.91 | ALK (0.53) | ALKINSRBTKMAP4K1MET | |
| SCHEMBL29651250 | 0.86 | MAP4K1 (0.62) | ALKMAP4K1 | |
| SCHEMBL22864471 | 0.86 | MAP4K1 (0.62) | ALKMAP4K1 | |
| SCHEMBL24729053 | 0.84 | MAP4K1 (0.52) | ALKMAP4K1 | |
| SCHEMBL29650970 | 0.84 | MAP4K1 (0.52) | ALKMAP4K1 | |
| SCHEMBL22864730 | 0.82 | MAP4K1 (0.60) | ALKMAP4K1 | |
| SCHEMBL29651023 | 0.82 | MAP4K1 (0.60) | ALKMAP4K1 | |
| SCHEMBL22864701 | 0.82 | ALK (0.62) | ALKINSRMAP4K1 | |
| SCHEMBL29650974 | 0.82 | ALK (0.62) | ALKINSRMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114555585-B | HPK1 inhibitors and uses thereof | 锐格药业公司 | 2025-02-11 | — | — | CN | disclosed |
| CN-114555585-A | HPK1 inhibitors and uses thereof | 上海齐鲁锐格医药研发有限公司 | 2022-05-27 | — | — | CN | disclosed |
| EP-3994133-A1 | HPK1 INHIBITORS AND USES THEREOF | Qilu Regor Therapeutics Inc. (CN) | 2022-05-11 | — | — | EP | disclosed |