Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.67 |
| ▸ | SRC | P12931 | 12/20 | 0.61 |
| ▸ | ABL1 | P00519 | 10/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.61 |
| ▸ | EGFR | P00533 | 7/20 | 0.61 |
| ▸ | HCK | P08631 | 6/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.61 |
| ▸ | PRKDC | P78527 | 6/20 | 0.61 |
| ▸ | KDR | P35968 | 5/20 | 0.61 |
| ▸ | MTOR | P42345 | 5/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.61 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.61 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.60 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.48 |
| ▸ | CSK | P41240 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | ABL2 | P42684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691 | 1.00 | PIK3CD (0.67) | PIK3CDSRCABL1PIK3CGEGFR | |
| SCHEMBL10559 | 0.93 | PIK3CD (0.77) | PIK3CDSRCABL1PIK3CGEGFR | |
| SCHEMBL29651630 | 0.93 | PIK3CD (0.77) | PIK3CDSRCABL1PIK3CGEGFR | |
| SCHEMBL129935 | 0.90 | PIK3CD (0.67) | PIK3CDSRCABL1PIK3CGEGFR | |
| SCHEMBL29651723 | 0.90 | PIK3CD (0.67) | PIK3CDSRCABL1PIK3CGEGFR | |
| SCHEMBL21467051 | 0.89 | PIK3CD (0.58) | PIK3CDSRCABL1PIK3CGEGFR | |
| SCHEMBL11083 | 0.89 | PIK3CD (0.75) | PIK3CDSRCABL1PIK3CGEGFR | |
| SCHEMBL29651608 | 0.89 | PIK3CD (0.75) | PIK3CDSRCABL1PIK3CGEGFR | |
| SCHEMBL13797 | 0.88 | PIK3CD (0.77) | PIK3CDSRCABL1PIK3CGEGFR | |
| SCHEMBL29651781 | 0.88 | PIK3CD (0.77) | PIK3CDSRCABL1PIK3CGEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117222413-A | Methods and combinations for treating tumors | 同润生物医药(上海)有限公司 | 2023-12-12 | — | — | CN | claimed |
| WO-2022171121-A1 | METHOD AND COMBINATION FOR TREATING TUMORS | 同润生物医药(上海)有限公司 | 2022-08-18 | — | — | WO | claimed |
| CN-117222413-A | Methods and combinations for treating tumors | 同润生物医药(上海)有限公司 | 2023-12-12 | — | — | CN | disclosed |
| WO-2022171121-A1 | METHOD AND COMBINATION FOR TREATING TUMORS | 同润生物医药(上海)有限公司 | 2022-08-18 | — | — | WO | disclosed |
| EP-2916868-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING A PDE4 INHIBITOR AND A PI3 DELTA OR DUAL PI3 DELTA-GAMMA KINASE INHIBITOR | RHIZEN PHARMACEUTICALS S A (CH) | 2022-05-11 | — | — | EP | disclosed |