SCHEMBL29653581

SCHEMBL29653581

C[C@H](NC(=O)c1cnc(Cl)c(-c2cc(F)cc(F)c2)c1N1CC[C@](C)(NC(=O)OC(C)(C)C)C1)C1CC1

nearest known ligand 0.34

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ RAF1 P04049 1/20 0.34
▸ RET P07949 10/20 0.34
▸ IDO1 P14902 2/20 0.33
▸ IRAK4 Q9NWZ3 1/20 0.32
▸ JAK2 O60674 5/20 0.32
▸ NTRK1 P04629 5/20 0.32
▸ KCNK3 O14649 1/20 0.31
▸ CHRNA1 P02708 1/20 0.30
▸ CYP2C8 P10632 1/20 0.30
▸ CYP2C9 P11712 1/20 0.30
▸ CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29653430 0.93 RAF1 (0.36) RAF1RETIRAK4JAK2NTRK1
SCHEMBL29653498 0.91 RAF1 (0.36) RAF1RETIRAK4JAK2NTRK1
SCHEMBL22976804 0.90 IDO1 (0.34) IDO1IRAK4JAK2NTRK1CHRNA1
SCHEMBL22976805 0.90 IDO1 (0.34) IDO1IRAK4JAK2NTRK1CHRNA1
SCHEMBL22976800 0.90 IDO1 (0.34) IDO1IRAK4JAK2NTRK1CHRNA1
SCHEMBL29653493 0.90 RET (0.38) RAF1RETIRAK4JAK2
SCHEMBL31243144 0.90 RET (0.38) RAF1RETIRAK4JAK2
SCHEMBL29653478 0.89 RAF1 (0.35) RAF1RETJAK2NTRK1KCNK3
SCHEMBL31243146 0.87 RET (0.33) RAF1RETIDO1
SCHEMBL29653404 0.87 RET (0.33) RAF1RETIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12600709-B2 Nonpeptide somatostatin type 5 receptor agonists and uses thereof Crinetics Pharmaceuticals, Inc. (US) 2026-04-14 — — US disclosed
US-20250136573-A1 NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF Crinetics Pharmaceuticals, Inc. 2025-05-01 — — US disclosed
US-11479540-B2 Nonpeptide somatostatin type 5 receptor agonists and uses thereof Crinetics Pharmaceuticals, Inc. (US) 2022-10-25 — — US disclosed
EP-4013748-A1 NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF Crinetics Pharmaceuticals, Inc. (US) 2022-06-22 — — EP disclosed
US-20220144802-A1 NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF Crinetics Pharmaceuticals, Inc. 2022-05-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220144802-A1 NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF SSTR5, SSTR4, SSTR3 RAF1 3313/4885RET 478/4885IDO1 2292/4885
US-11479540-B2 Nonpeptide somatostatin type 5 receptor agonists and uses thereof SSTR5, SSTR4, SSTR3 RAF1 3313/4885RET 478/4885IDO1 2292/4885
US-20250136573-A1 NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF SSTR5, SSTR4, SSTR3 RAF1 3313/4885RET 478/4885IDO1 2292/4885
US-12600709-B2 Nonpeptide somatostatin type 5 receptor agonists and uses thereof SSTR5, SSTR4, GLP1R RAF1 2233/4885RET 398/4885IDO1 2310/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback