Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.82 |
| ▸ | ERBB2 | P04626 | 19/20 | 0.82 |
| ▸ | STK25 | O00506 | 1/20 | 0.73 |
| ▸ | CIT | O14578 | 1/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.73 |
| ▸ | GAK | O14976 | 1/20 | 0.73 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.73 |
| ▸ | JAK2 | O60674 | 1/20 | 0.73 |
| ▸ | STK17B | O94768 | 1/20 | 0.73 |
| ▸ | STK10 | O94804 | 1/20 | 0.73 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.73 |
| ▸ | ABL1 | P00519 | 1/20 | 0.73 |
| ▸ | LCK | P06239 | 1/20 | 0.73 |
| ▸ | FYN | P06241 | 1/20 | 0.73 |
| ▸ | FES | P07332 | 1/20 | 0.73 |
| ▸ | CSF1R | P07333 | 1/20 | 0.73 |
| ▸ | YES1 | P07947 | 1/20 | 0.73 |
| ▸ | LYN | P07948 | 1/20 | 0.73 |
| ▸ | MET | P08581 | 1/20 | 0.73 |
| ▸ | HCK | P08631 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29501005 | 1.00 | EGFR (0.82) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL29670930 | 1.00 | EGFR (0.82) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL2132745 | 1.00 | EGFR (0.82) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL29780816 | 1.00 | EGFR (0.82) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL2132756 | 1.00 | EGFR (0.82) | EGFRERBB2STK25CITCHEK1 | |
| Maleic Acid SCHEMBL23420360 | 0.97 | EGFR (0.78) | EGFRERBB2STK25CITCHEK1 | |
| Maleic Acid SCHEMBL29420770 | 0.97 | EGFR (0.78) | EGFRERBB2STK25CITCHEK1 | |
| Maleic Acid SCHEMBL29780804 | 0.97 | EGFR (0.78) | EGFRERBB2STK25CITCHEK1 | |
| Maleic Acid SCHEMBL23420362 | 0.97 | EGFR (0.78) | EGFRERBB2STK25CITCHEK1 | |
| Maleic Acid SCHEMBL29500961 | 0.97 | EGFR (0.78) | EGFRERBB2STK25CITCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111875539-B | Preparation method of EGFR (epidermal growth factor receptor) molecular targeted antitumor drug | 苏中药业集团股份有限公司 | 2022-06-21 | — | — | CN | claimed |
| CN-114605321-A | Impurities of substituted butene amide raw material and preparation product and analysis method thereof | 苏中药业集团股份有限公司 | 2022-06-10 | — | — | CN | claimed |
| CN-113493414-B | Deuterated substituted butenamide and preparation method and application thereof | 苏中药业集团股份有限公司 | 2024-09-27 | — | — | CN | disclosed |
| CN-113493413-B | Substituted butenamide-N-oxide and preparation method and application thereof | 苏中药业集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-111875539-B | Preparation method of EGFR (epidermal growth factor receptor) molecular targeted antitumor drug | 苏中药业集团股份有限公司 | 2022-06-21 | — | — | CN | disclosed |
| CN-111875539-B | Preparation method of EGFR (epidermal growth factor receptor) molecular targeted antitumor drug | 苏中药业集团股份有限公司 | 2022-06-21 | — | — | CN | disclosed |
| CN-114605321-A | Impurities of substituted butene amide raw material and preparation product and analysis method thereof | 苏中药业集团股份有限公司 | 2022-06-10 | — | — | CN | disclosed |