Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 14/20 | 0.59 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19748946 | 1.00 | PARP1 (0.59) | PARP1TNKSTNKS2MAPTENPP1 | |
| SCHEMBL29655259 | 0.85 | PARP1 (0.64) | PARP1ENPP1LMNA | |
| SCHEMBL19748474 | 0.85 | PARP1 (0.64) | PARP1ENPP1LMNA | |
| SCHEMBL19747669 | 0.84 | PARP1 (0.63) | PARP1ENPP1LMNA | |
| SCHEMBL29655088 | 0.84 | PARP1 (0.63) | PARP1ENPP1LMNA | |
| SCHEMBL29483966 | 0.84 | PARP1 (0.72) | PARP1ENPP1LMNA | |
| SCHEMBL4572876 | 0.84 | PARP1 (0.72) | PARP1ENPP1LMNA | |
| SCHEMBL19748607 | 0.84 | PARP1 (0.68) | PARP1ENPP1LMNA | |
| SCHEMBL29655224 | 0.84 | PARP1 (0.68) | PARP1ENPP1LMNA | |
| SCHEMBL29654940 | 0.83 | PARP1 (0.61) | PARP1ENPP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109843874-B | Phthalazine derivatives useful as inhibitors of PARP1, PARP2 and/or tubulin for the treatment of cancer | 加利福尼亚大学董事会 | 2022-05-27 | — | — | CN | disclosed |