Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.53 |
| ▸ | PI4KA | P42356 | 2/20 | 0.50 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.50 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942722 | 1.00 | EGFR (0.53) | EGFRPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL6419640 | 0.83 | PI4KA (0.50) | EGFRPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL29882957 | 0.83 | PI4KA (0.50) | EGFRPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL25254426 | 0.75 | EGFR (0.49) | EGFRPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL6836416 | 0.75 | EGFR (0.46) | EGFR | |
| SCHEMBL17362671 | 0.74 | PI4KA (0.42) | EGFRPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL6839396 | 0.70 | EGFR (1.00) | EGFR | |
| SCHEMBL1570954 | 0.70 | PI4KA (0.55) | EGFRPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL6096033 | 0.70 | PI4KA (0.57) | EGFRPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL30400679 | 0.70 | PI4KA (0.55) | EGFRPI4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114539245-A | Pyrimidine-fused ring derivative-containing regulator, and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2022-05-27 | — | — | CN | disclosed |