Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | ADK | P55263 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25407620 | 0.84 | MAP4K4 (0.44) | MAP4K4RETCYP11B2EIF2AK4GPR119 | |
| SCHEMBL111508 | 0.84 | MAP4K4 (0.66) | MAP4K4GPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL29545935 | 0.84 | MAP4K4 (0.66) | MAP4K4GPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL22165640 | 0.81 | RET (0.49) | MAP4K4RETCYP11B2EIF2AK4GPR119 | |
| SCHEMBL114257 | 0.80 | MAP4K4 (0.61) | MAP4K4GPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL29461507 | 0.80 | PDE10A (0.54) | MAP4K4CYP11B2GPR119CKS1BSKP1 | |
| SCHEMBL25407560 | 0.78 | JAK2 (0.47) | MAP4K4RETEIF2AK4GPR119HDAC2 | |
| SCHEMBL22470063 | 0.77 | KMT2A (0.43) | RETCYP11B2EIF2AK4GPR119EGLN2 | |
| SCHEMBL23538928 | 0.77 | RET (0.49) | RETCYP11B2EIF2AK4GPR119EGLN2 | |
| SCHEMBL22092941 | 0.77 | RET (0.49) | RETCYP11B2EIF2AK4GPR119HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109721620-B | HPK1 inhibitors and uses thereof | 药捷安康(南京)科技股份有限公司 | 2022-05-13 | — | — | CN | disclosed |