Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 5/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.47 |
| ▸ | STS | P08842 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22701140 | 1.00 | PTPN2 (0.50) | PTPN2PTPN1PTPN6PARP1PARP2 | |
| SCHEMBL23316236 | 0.82 | PTPN2 (0.56) | PTPN2PTPN1PTPN6PARP1ABL1 | |
| SCHEMBL26025076 | 0.79 | PTPN2 (0.54) | PTPN2PTPN1PTPN6PARP1PARP2 | |
| SCHEMBL25362245 | 0.79 | PTPN2 (0.54) | PTPN2PTPN1PTPN6PARP1PARP2 | |
| SCHEMBL30496051 | 0.79 | PTPN2 (0.54) | PTPN2PTPN1PTPN6PARP1PARP2 | |
| SCHEMBL22701155 | 0.78 | PTPN2 (0.50) | PTPN2PTPN1PTPN6PARP1PARP2 | |
| SCHEMBL24496409 | 0.78 | PTPN2 (0.52) | PTPN2PTPN1PTPN6PARP1PARP2 | |
| SCHEMBL29596815 | 0.78 | PTPN2 (0.52) | PTPN2PTPN1PTPN6PARP1PARP2 | |
| SCHEMBL22701189 | 0.77 | PARP1 (0.47) | PTPN2PTPN1PTPN6PARP1PARP2 | |
| SCHEMBL1534310 | 0.76 | PTPN2 (0.72) | PTPN2PTPN1PTPN6ABL1RIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220227729-A1 | IDENTIFICATION AND USE OF KRAS INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2022-07-21 | — | — | US | disclosed |
| EP-3972963-A1 | IDENTIFICATION AND USE OF KRAS INHIBITORS | Bayer Aktiengesellschaft (DE) | 2022-03-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220227729-A1 | IDENTIFICATION AND USE OF KRAS INHIBITORS | KRAS, NRAS, BRCA1 | PTPN2 330/4885PTPN1 150/4885PTPN6 282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.