Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 5/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL166437 | 1.00 | TDP1 (0.56) | TDP1L3MBTL1MAPTCYP2C9CYP2C19 | |
| SCHEMBL12939114 | 0.94 | TDP1 (0.56) | TDP1L3MBTL1MAPTCYP2C9CYP2C19 | |
| SCHEMBL167317 | 0.92 | MCL1 (0.57) | TDP1L3MBTL1MAPTCYP2C9CYP2C19 | |
| SCHEMBL6449136 | 0.88 | MAPT (0.61) | TDP1L3MBTL1MAPTCYP2C9CYP2C19 | |
| SCHEMBL1036349 | 0.87 | MAPT (0.59) | TDP1L3MBTL1MAPTCYP2C9CYP2C19 | |
| SCHEMBL2946703 | 0.86 | MAOB (0.57) | TDP1L3MBTL1MAPTCYP2C9CYP2C19 | |
| SCHEMBL165982 | 0.86 | MCL1 (0.57) | TDP1L3MBTL1MAPTCYP2C9CYP2C19 | |
| SCHEMBL22918087 | 0.85 | MAOB (0.53) | TDP1L3MBTL1MAPTCYP2C9CYP2C19 | |
| SCHEMBL29660966 | 0.85 | MAOB (0.53) | TDP1L3MBTL1MAPTCYP2C9CYP2C19 | |
| SCHEMBL18854498 | 0.85 | MAOB (0.53) | TDP1L3MBTL1MAPTCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114616226-B | Pyridine derivatives as TMEM16A modulators for the treatment of respiratory disorders | TMEM16A有限公司 | 2025-03-04 | — | — | CN | disclosed |
| CN-114616226-A | Pyridine derivatives as TMEM16A modulators for the treatment of respiratory disorders | TMEM16A有限公司 | 2022-06-10 | — | — | CN | disclosed |
| EP-4003516-A1 | PYRIDINE DERIVATIVES AS TMEM16A MODULATORS FOR USE IN THE TREATMENT OF RESPIRATORY CONDITIONS | TMEM16A LIMITED (GB) | 2022-06-01 | — | — | EP | disclosed |