Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.52 |
| ▸ | INSR | P06213 | 8/20 | 0.52 |
| ▸ | IGF1R | P08069 | 8/20 | 0.52 |
| ▸ | EGFR | P00533 | 12/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 2/20 | 0.44 |
| ▸ | GAK | O14976 | 2/20 | 0.44 |
| ▸ | ERN1 | O75460 | 2/20 | 0.44 |
| ▸ | STK10 | O94804 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | FES | P07332 | 2/20 | 0.44 |
| ▸ | YES1 | P07947 | 2/20 | 0.44 |
| ▸ | HCK | P08631 | 2/20 | 0.44 |
| ▸ | ROS1 | P08922 | 2/20 | 0.44 |
| ▸ | FER | P16591 | 2/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.44 |
| ▸ | LTK | P29376 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327532 | 1.00 | ALK (0.52) | ALKINSRIGF1REGFRBMPR1B | |
| SCHEMBL24326981 | 0.90 | EGFR (0.62) | ALKINSRIGF1REGFRROS1 | |
| SCHEMBL24326973 | 0.87 | ALK (0.69) | ALKINSRIGF1REGFRBMPR1B | |
| SCHEMBL26778415 | 0.87 | ALK (0.58) | ALKINSRIGF1REGFRMAPK8 | |
| SCHEMBL29015731 | 0.86 | ALK (0.53) | ALKINSRIGF1REGFRBMPR1B | |
| SCHEMBL30425915 | 0.86 | ALK (0.53) | ALKINSRIGF1REGFRBMPR1B | |
| SCHEMBL30725920 | 0.83 | EGFR (0.54) | ALKINSRIGF1REGFRROS1 | |
| SCHEMBL27048896 | 0.83 | EGFR (0.54) | ALKINSRIGF1REGFRROS1 | |
| SCHEMBL24327556 | 0.81 | ALK (0.55) | ALKINSRIGF1REGFRFGFR1 | |
| SCHEMBL26778417 | 0.81 | ALK (0.51) | ALKINSRIGF1REGFRTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4217348-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BeiGene, Ltd. (KY) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |