SCHEMBL29661844

SCHEMBL29661844

Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cnc(N4CC(N(C)C(=O)OC(C)(C)C)C4)c(C#N)c3c2=O)c2scc(C(=O)O)c2n1

nearest known ligand 0.83

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ EIF4EBP1 Q13541 20/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28704404 1.00 EIF4EBP1 (0.83) EIF4EBP1
SCHEMBL28718641 0.96 EIF4EBP1 (0.77) EIF4EBP1
SCHEMBL28721906 0.90 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL22866553 0.88 EIF4EBP1 (0.86) EIF4EBP1
SCHEMBL29661943 0.88 EIF4EBP1 (0.86) EIF4EBP1
SCHEMBL28718331 0.88 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29661936 0.88 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650419 0.87 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650486 0.86 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL22866598 0.85 EIF4EBP1 (0.86) EIF4EBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3994139-A1 EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS Effector Therapeutics Inc. (US) 2022-05-11 — — EP disclosed
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