SCHEMBL29661933

SCHEMBL29661933

Cc1nc2cnc(F)c(C#N)c2c(=O)n1CC#Cc1ccc(Cl)cc1-c1ccnc2c(C(=O)OC(C)(C)C)csc12

nearest known ligand 0.69

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ EIF4EBP1 Q13541 20/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22866445 1.00 EIF4EBP1 (0.69) EIF4EBP1
SCHEMBL29661839 0.94 EIF4EBP1 (0.71) EIF4EBP1
SCHEMBL22866564 0.94 EIF4EBP1 (0.71) EIF4EBP1
SCHEMBL22866520 0.91 EIF4EBP1 (0.82) EIF4EBP1
SCHEMBL29661902 0.91 EIF4EBP1 (0.82) EIF4EBP1
SCHEMBL29661874 0.87 EIF4EBP1 (0.76) EIF4EBP1
SCHEMBL22866566 0.87 EIF4EBP1 (0.76) EIF4EBP1
SCHEMBL22866443 0.85 EIF4EBP1 (0.91) EIF4EBP1
SCHEMBL29468134 0.85 EIF4EBP1 (0.91) EIF4EBP1
SCHEMBL22866565 0.84 EIF4EBP1 (0.84) EIF4EBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3994139-A1 EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS Effector Therapeutics Inc. (US) 2022-05-11 — — EP disclosed
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