Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.62 |
| ▸ | CD63 | P08962 | 2/20 | 0.62 |
| ▸ | AURKA | O14965 | 2/20 | 0.62 |
| ▸ | RAF1 | P04049 | 10/20 | 0.60 |
| ▸ | BRAF | P15056 | 10/20 | 0.60 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.56 |
| ▸ | BTK | Q06187 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | ROS1 | P08922 | 1/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.52 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.52 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24864087 | 1.00 | SYK (0.62) | SYKCD63AURKARAF1BRAF | |
| SCHEMBL2543802 | 0.84 | SYK (0.74) | SYKCD63AURKABRAFBTK | |
| SCHEMBL4336940 | 0.82 | SYK (0.68) | SYKCD63AURKABTKJAK2 | |
| SCHEMBL3795040 | 0.81 | AURKA (0.64) | SYKCD63AURKABTKJAK2 | |
| SCHEMBL4808681 | 0.81 | BTK (0.78) | SYKCD63AURKABTKJAK2 | |
| SCHEMBL23911841 | 0.81 | AURKA (0.70) | SYKCD63AURKABTKJAK2 | |
| SCHEMBL2481740 | 0.80 | SYK (0.80) | SYKCD63AURKABTKJAK2 | |
| SCHEMBL3803344 | 0.80 | SYK (0.71) | SYKCD63AURKABTKJAK2 | |
| SCHEMBL24864095 | 0.80 | AURKA (0.60) | SYKCD63AURKAEPHB4BTK | |
| SCHEMBL2482740 | 0.79 | SYK (0.74) | SYKCD63AURKABTKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113480543-B | 2,6, 8-polysubstituted imidazo [1,2-a ] pyrazine and synthetic method and application thereof | 无锡市第二人民医院 | 2022-05-17 | — | — | CN | disclosed |