Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.64 |
| ▸ | SYK | P43405 | 9/20 | 0.62 |
| ▸ | CD63 | P08962 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29664232 | 0.92 | AURKA (0.53) | AURKASYKCD63ALDH1A1POLB | |
| SCHEMBL24864102 | 0.88 | AURKA (0.62) | AURKASYKCD63ALDH1A1POLB | |
| SCHEMBL2216977 | 0.83 | AURKA (0.77) | AURKASYKCD63ALDH1A1POLB | |
| SCHEMBL12514839 | 0.81 | AURKA (0.79) | AURKASYKCD63BTK | |
| SCHEMBL24864099 | 0.77 | AURKA (0.61) | AURKASYKCD63ALDH1A1POLB | |
| SCHEMBL4838189 | 0.77 | SYK (0.65) | AURKASYKCD63BTK | |
| SCHEMBL4836906 | 0.77 | SYK (0.67) | AURKASYKCD63BTK | |
| SCHEMBL2481780 | 0.76 | SYK (1.00) | AURKASYKCD63 | |
| SCHEMBL4838127 | 0.76 | SYK (0.67) | AURKASYKCD63BTK | |
| SCHEMBL4835147 | 0.76 | SYK (0.67) | AURKASYKCD63 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113480543-B | 2,6, 8-polysubstituted imidazo [1,2-a ] pyrazine and synthetic method and application thereof | 无锡市第二人民医院 | 2022-05-17 | — | — | CN | disclosed |