Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | MTOR | P42345 | 3/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.35 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29665249 | 0.98 | MAP4K4 (0.44) | MAP4K4CLK1DYRK1ACLK2DYRK2 | |
| SCHEMBL24478797 | 0.98 | MAP4K4 (0.44) | MAP4K4CLK1DYRK1ACLK2DYRK2 | |
| SCHEMBL2719952 | 0.84 | KDM4E (0.44) | CLK1DYRK1ACLK2DYRK2CLK4 | |
| SCHEMBL24478448 | 0.79 | PIK3CD (0.45) | MAP4K4CLK1DYRK1APIK3CAMTOR | |
| SCHEMBL29665301 | 0.77 | PIK3CD (0.44) | MAP4K4CLK1DYRK1APIK3CAMTOR | |
| SCHEMBL4558986 | 0.74 | KDM4E (0.40) | CCNA2CDK2CCNA1KDM4E | |
| SCHEMBL24469174 | 0.72 | EGFR (0.39) | MAP4K4CLK1DYRK1ACLK2DYRK2 | |
| Hydrochloric Acid SCHEMBL29665261 | 0.72 | FYN (0.44) | RAF1BRAFKDM4E | |
| SCHEMBL24478653 | 0.71 | FYN (0.46) | RAF1BRAFKDM4E | |
| SCHEMBL12861090 | 0.70 | SRC (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4251617-A1 | (AZA)QUINOLINE 4-AMINES DERIVATIVES AS P2X3 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2023-10-04 | — | — | EP | disclosed |
| WO-2022112491-A1 | (AZA)QUINOLINE 4-AMINES DERIVATIVES AS P2X3 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-06-02 | — | — | WO | disclosed |