Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.61 |
| ▸ | CD38 | P28907 | 1/20 | 0.61 |
| ▸ | RAF1 | P04049 | 2/20 | 0.58 |
| ▸ | BRAF | P15056 | 2/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.56 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17858789 | 1.00 | EGFR (0.61) | EGFRERBB2ERBB4CD38RAF1 | |
| SCHEMBL17858691 | 0.86 | EGFR (0.61) | EGFRERBB2CD38RAF1BRAF | |
| SCHEMBL29793305 | 0.86 | EGFR (0.61) | EGFRERBB2CD38RAF1BRAF | |
| SCHEMBL19729005 | 0.84 | CD38 (0.61) | EGFRERBB2ERBB4CD38PIK3CA | |
| SCHEMBL29793388 | 0.84 | IRAK4 (0.53) | EGFRCD38RAF1BRAFPIK3CA | |
| SCHEMBL17858798 | 0.84 | IRAK4 (0.53) | EGFRCD38RAF1BRAFPIK3CA | |
| SCHEMBL17858730 | 0.82 | EGFR (0.74) | EGFRERBB2ERBB4CD38RAF1 | |
| SCHEMBL29793406 | 0.82 | EGFR (0.74) | EGFRERBB2ERBB4CD38RAF1 | |
| SCHEMBL15051470 | 0.81 | RAF1 (0.66) | EGFRERBB2ERBB4CD38RAF1 | |
| SCHEMBL17845917 | 0.81 | EGFR (0.69) | EGFRERBB2ERBB4CD38RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11607414-B2 | Small molecule inhibitors of EGFR and PI3K | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2023-03-21 | — | — | US | disclosed |
| US-20220202818-A1 | COMBINATION WITH CHECKPOINT INHIBITORS TO TREAT CANCER | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11607414-B2 | Small molecule inhibitors of EGFR and PI3K | EGFR, ERBB2, ERBB3 | EGFR 1/4885ERBB2 2/4885ERBB4 4/4885 |
| US-20220202818-A1 | COMBINATION WITH CHECKPOINT INHIBITORS TO TREAT CANCER | CD274, PDCD1, PDCD1LG2 | EGFR 378/4885ERBB2 1112/4885ERBB4 1918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.