Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 3/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2209145 | 0.91 | MAPT (0.48) | MAPTLMNATP53ENPP3MEN1 | |
| SCHEMBL2973076 | 0.89 | MAPT (0.49) | MAPTLMNATP53ENPP3MEN1 | |
| SCHEMBL2972776 | 0.88 | MAPT (0.49) | MAPTLMNATP53ENPP3MEN1 | |
| SCHEMBL15663474 | 0.88 | MAPT (0.51) | MAPTLMNATP53ENPP3MEN1 | |
| SCHEMBL2209628 | 0.87 | MAPT (0.52) | MAPTLMNATP53ENPP3MEN1 | |
| SCHEMBL2209836 | 0.87 | MAPT (0.58) | MAPTLMNATP53ENPP3MEN1 | |
| SCHEMBL2210282 | 0.87 | CA9 (0.45) | MAPTLMNATP53ENPP3MEN1 | |
| SCHEMBL2212027 | 0.87 | MAPT (0.46) | MAPTLMNATP53ENPP3MEN1 | |
| SCHEMBL15663476 | 0.86 | MAPT (0.46) | MAPTLMNATP53ENPP3MEN1 | |
| SCHEMBL2210745 | 0.86 | MAPT (0.48) | MAPTLMNATP53ENPP3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776857-B2 | Aurora kinase modulators and method of use | AMGEN INC. (US) | 2010-08-17 | — | — | US | claimed |
| EP-2137177-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-05-07 | — | — | EP | disclosed |