SCHEMBL29669288

SCHEMBL29669288

COc1ccc(CN(c2nccs2)S(=O)(=O)c2cc(Cl)c(N[C@@H](C)c3ccccc3Cl)cc2F)c(OC)c1

nearest known ligand 0.55

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SCN1A P35498 20/20 0.55
SCN5A Q14524 20/20 0.55
SCN8A Q9UQD0 20/20 0.55
SCN1B Q07699 3/20 0.45
NR1I2 O75469 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20238439 1.00 SCN1A (0.55) SCN1ASCN5ASCN8ASCN1BNR1I2
SCHEMBL20238443 1.00 SCN1A (0.55) SCN1ASCN5ASCN8ASCN1BNR1I2
SCHEMBL29669198 0.96 SCN1A (0.55) SCN1ASCN5ASCN8ASCN1BNR1I2
SCHEMBL20237827 0.96 SCN1A (0.55) SCN1ASCN5ASCN8ASCN1BNR1I2
SCHEMBL20237828 0.96 SCN1A (0.55) SCN1ASCN5ASCN8ASCN1BNR1I2
SCHEMBL29669098 0.96 SCN1A (0.55) SCN1ASCN5ASCN8ASCN1BNR1I2
SCHEMBL20238425 0.92 SCN1A (0.58) SCN1ASCN5ASCN8ASCN1BNR1I2
SCHEMBL29669049 0.92 SCN1A (0.58) SCN1ASCN5ASCN8ASCN1BNR1I2
SCHEMBL20238423 0.92 SCN1A (0.58) SCN1ASCN5ASCN8ASCN1BNR1I2
SCHEMBL20238480 0.92 SCN1A (0.56) SCN1ASCN5ASCN8ASCN1BNR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110325531-B Benzenesulfonamides and their use as therapeutic agents 泽农医药公司 2022-05-27 CN disclosed