Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefadroxil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.94 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.94 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.94 |
| ▸ | MEN1 | O00255 | 5/20 | 0.94 |
| ▸ | SLC15A2 | Q16348 | 3/20 | 0.94 |
| ▸ | LMNA | P02545 | 2/20 | 0.94 |
| ▸ | ESR1 | P03372 | 1/20 | 0.94 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.94 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.80 |
| ▸ | HPGD | P15428 | 3/20 | 0.80 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.80 |
| ▸ | BLM | P54132 | 2/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.80 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.80 |
| ▸ | HTR2B | P41595 | 1/20 | 0.80 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.71 |
| ▸ | DRD2 | P14416 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefadroxil SCHEMBL1821440 | 0.98 | MAPT (0.98) | MAPTHSD17B10KMT2AMEN1SLC15A2 | |
| Cefadroxil SCHEMBL1821442 | 0.98 | MAPT (0.98) | MAPTHSD17B10KMT2AMEN1SLC15A2 | |
| Cefadroxil SCHEMBL10945661 | 0.98 | MAPT (0.98) | MAPTHSD17B10KMT2AMEN1SLC15A2 | |
| Cefadroxil SCHEMBL146152 | 0.98 | MAPT (0.98) | MAPTHSD17B10KMT2AMEN1SLC15A2 | |
| Cefadroxil SCHEMBL9807365 | 0.98 | MAPT (0.98) | MAPTHSD17B10KMT2AMEN1SLC15A2 | |
| Cefadroxil SCHEMBL2221955 | 0.98 | MAPT (0.98) | MAPTHSD17B10KMT2AMEN1SLC15A2 | |
| Cefadroxil SCHEMBL28094893 | 0.98 | MAPT (0.98) | MAPTHSD17B10KMT2AMEN1SLC15A2 | |
| Cefadroxil SCHEMBL33620 | 0.98 | MAPT (0.98) | MAPTHSD17B10KMT2AMEN1SLC15A2 | |
| Cefadroxil SCHEMBL19704546 | 0.97 | MAPT (0.96) | MAPTHSD17B10KMT2AMEN1SLC15A2 | |
| Cefadroxil SCHEMBL11589366 | 0.97 | MAPT (0.96) | MAPTHSD17B10KMT2AMEN1SLC15A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427178-A2 | DERMAL DELIVERY COMPOSITIONS COMPRISING ACTIVE AGENT-CALCIUM PHOSPHATE PARTICLE COMPLEXES AND METHODS OF USING THE SAME | Laboratory Skin Care, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129819-A2 | DERMAL DELIVERY COMPOSITIONS COMPRISING ACTIVE AGENT-CALCIUM PHOSPHATE PARTICLE COMPLEXES AND METHODS OF USING THE SAME | LABORATORY SKIN CARE, INC. (US) | 2010-11-11 | — | — | WO | disclosed |