Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.46 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24484069 | 0.81 | MAPT (0.45) | GAAGFERMAPTMEN1TSHR | |
| SCHEMBL24484076 | 0.77 | GAA (0.54) | GAAGFERMAPTMEN1KMT2A | |
| SCHEMBL24484087 | 0.77 | SNCA (0.46) | GAAGFERMAPTMEN1KMT2A | |
| SCHEMBL4499194 | 0.73 | AVPR2 (0.55) | GAAGFERMAPTMEN1TSHR | |
| SCHEMBL18808535 | 0.73 | AVPR2 (0.55) | GAAGFERMAPTMEN1KMT2A | |
| SCHEMBL3587206 | 0.73 | KDM4E (0.43) | GAAGFERMAPTMEN1KMT2A | |
| SCHEMBL24484650 | 0.72 | GAA (0.47) | GAAGFERMAPTMEN1KMT2A | |
| SCHEMBL23297307 | 0.72 | MAPT (0.71) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL23297266 | 0.72 | MAPT (0.71) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL16037273 | 0.72 | MAPT (0.53) | MAPTMEN1TSHRKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115384-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. (US) | 2022-06-02 | — | — | WO | disclosed |