Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.64 |
| ▸ | BRD4 | O60885 | 3/20 | 0.61 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.60 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.60 |
| ▸ | TNF | P01375 | 1/20 | 0.60 |
| ▸ | IL1B | P01584 | 1/20 | 0.60 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.60 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.56 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2383485 | 1.00 | CRBN (0.64) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL13641027 | 0.92 | CRBN (0.62) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL30249970 | 0.91 | CRBN (0.65) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL805995 | 0.90 | CRBN (0.60) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL25263045 | 0.90 | CRBN (0.64) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL22464605 | 0.90 | CRBN (0.64) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL29453444 | 0.90 | CRBN (0.64) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL2383001 | 0.90 | CRBN (0.64) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL2384439 | 0.90 | CRBN (0.64) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL26321021 | 0.90 | CRBN (0.64) | CRBNBRD4IKZF1IKZF3TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113004251-B | Quinazoline derivative containing 2-nitroimidazole and application thereof | 郑州大学第一附属医院 | 2022-09-27 | — | — | CN | claimed |
| CN-112608302-B | Quinazoline derivative for activating target ubiquitination degradation of EGFR protein through low-oxygen reduction and application thereof | 郑州大学第一附属医院 | 2022-05-24 | — | — | CN | claimed |
| WO-2025010326-A2 | DIMERIC IMMUNO-MODULATORY COMPOUNDS AGAINST CEREBLON-BASED MECHANISMS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2025-01-09 | — | — | WO | disclosed |
| CN-109415336-B | MDM2 protein degradation agent | 密执安大学评议会 | 2023-08-29 | — | — | CN | disclosed |
| CN-113004251-B | Quinazoline derivative containing 2-nitroimidazole and application thereof | 郑州大学第一附属医院 | 2022-09-27 | — | — | CN | disclosed |
| CN-112608302-B | Quinazoline derivative for activating target ubiquitination degradation of EGFR protein through low-oxygen reduction and application thereof | 郑州大学第一附属医院 | 2022-05-24 | — | — | CN | disclosed |