Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | NEK2 | P51955 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29680164 | 1.00 | CRBN (0.34) | CRBNSIGMAR1NEK2HTR2APOLB | |
| SCHEMBL24536621 | 0.94 | CRBN (0.33) | CRBNSIGMAR1NEK2POLBALDH1A1 | |
| SCHEMBL30887278 | 0.83 | CRBN (0.40) | CRBNNEK2 | |
| Hydrochloric Acid SCHEMBL31270250 | 0.82 | CRBN (0.39) | CRBNSIGMAR1 | |
| Hydrochloric Acid SCHEMBL15441503 | 0.80 | CRBN (0.38) | CRBNSIGMAR1 | |
| SCHEMBL19946508 | 0.76 | — | — | |
| SCHEMBL1401020 | 0.76 | — | — | |
| SCHEMBL24537298 | 0.75 | — | — | |
| SCHEMBL24535221 | 0.75 | — | — | |
| SCHEMBL4925004 | 0.74 | POLB (0.47) | CRBNPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4262807-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022132200-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |