Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.62 |
| ▸ | DDB1 | Q16531 | 17/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30830879 | 0.86 | CRBN (0.68) | CRBNDDB1POLB | |
| SCHEMBL21876964 | 0.83 | DDB1 (0.67) | CRBNDDB1GPR119 | |
| SCHEMBL23301226 | 0.83 | DDB1 (0.67) | CRBNDDB1GPR119 | |
| SCHEMBL29680886 | 0.82 | DDB1 (0.60) | CRBNDDB1GPR119 | |
| SCHEMBL31726711 | 0.82 | DDB1 (0.60) | CRBNDDB1GPR119 | |
| SCHEMBL29681080 | 0.82 | CRBN (0.55) | CRBNDDB1POLBGPR119 | |
| SCHEMBL24880592 | 0.81 | CRBN (0.62) | CRBNDDB1POLBGPR119 | |
| SCHEMBL30981212 | 0.81 | DDB1 (0.59) | CRBNDDB1POLBGPR119 | |
| SCHEMBL30981198 | 0.81 | DDB1 (0.59) | CRBNDDB1POLBGPR119 | |
| SCHEMBL31134647 | 0.81 | DDB1 (0.59) | CRBNDDB1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133285-A1 | MOLECULES AND METHODS RELATED TO TREATMNET OF DISORDERS ASSOCIATED WITH JAK-2 SIGNALING DYSFUNCTION | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2022-06-23 | — | — | WO | disclosed |