Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.78 |
| ▸ | THRB | P10828 | 4/20 | 0.72 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.70 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.69 |
| ▸ | KDR | P35968 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 3/20 | 0.62 |
| ▸ | CASP3 | P42574 | 1/20 | 0.61 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.61 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.61 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17544108 | 1.00 | MAPT (0.78) | MAPTTHRBRXFP1PTGS2KDR | |
| SCHEMBL2248135 | 0.90 | MAPT (0.90) | MAPTTHRBRXFP1PTGS2KDR | |
| SCHEMBL2243746 | 0.89 | MAPT (0.98) | MAPTTHRBRXFP1PTGS2KDR | |
| SCHEMBL2245479 | 0.86 | MAPT (0.87) | MAPTTHRBRXFP1PTGS2KDR | |
| SCHEMBL2245332 | 0.86 | MAPT (0.87) | MAPTTHRBRXFP1PTGS2KDR | |
| SCHEMBL2242938 | 0.84 | MAPT (0.87) | MAPTTHRBRXFP1PTGS2KDR | |
| SCHEMBL2245095 | 0.84 | MAPT (0.87) | MAPTTHRBRXFP1PTGS2KDR | |
| SCHEMBL2244624 | 0.84 | MAPT (1.00) | MAPTTHRBRXFP1PTGS2TSHR | |
| SCHEMBL2240507 | 0.84 | MAPT (0.87) | MAPTTHRBRXFP1PTGS2KDR | |
| SCHEMBL30402949 | 0.84 | MAPT (1.00) | MAPTTHRBRXFP1PTGS2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4006016-A2 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |