Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 4/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 10/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | NRAS | P01111 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24542640 | 1.00 | DYRK1A (0.39) | DYRK1ADYRK3DYRK2DYRK1BCCNT1 | |
| SCHEMBL24542626 | 0.89 | DYRK1A (0.38) | DYRK1ADYRK3DYRK2DYRK1BCCNT1 | |
| SCHEMBL29682996 | 0.89 | DYRK1A (0.38) | DYRK1ADYRK3DYRK2DYRK1BCCNT1 | |
| SCHEMBL24542585 | 0.89 | FYN (0.38) | DYRK1ADYRK3DYRK2DYRK1BCCNT1 | |
| SCHEMBL24975719 | 0.87 | FYN (0.33) | DYRK1ADYRK3DYRK2DYRK1BCCNT1 | |
| SCHEMBL30248571 | 0.87 | FYN (0.33) | DYRK1ADYRK3DYRK2DYRK1BCCNT1 | |
| SCHEMBL24231648 | 0.81 | RIPK2 (0.45) | GABRA1GABRG2GABRB3GABRA3RIPK2 | |
| SCHEMBL29372812 | 0.81 | RIPK2 (0.45) | GABRA1GABRG2GABRB3GABRA3RIPK2 | |
| SCHEMBL24542507 | 0.80 | FLT3 (0.46) | NRASFLT3 | |
| SCHEMBL24542868 | 0.80 | FLT3 (0.46) | NRASFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4262802-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022132936-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2022-06-23 | — | — | WO | disclosed |