Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.70 |
| ▸ | RAB9A | P51151 | 8/20 | 0.70 |
| ▸ | TP53 | P04637 | 3/20 | 0.70 |
| ▸ | HTT | P42858 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | GAA | P10253 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 7/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24074632 | 0.84 | NPC1 (0.58) | NPC1RAB9ATP53HTTKDM4E | |
| SCHEMBL16256827 | 0.82 | NPC1 (1.00) | NPC1RAB9ATP53HTTKDM4E | |
| SCHEMBL24074120 | 0.81 | NPC1 (0.50) | NPC1RAB9ATP53HTTKDM4E | |
| SCHEMBL741587 | 0.79 | NPC1 (0.76) | NPC1RAB9ATP53HTTKDM4E | |
| SCHEMBL24242616 | 0.79 | NPC1 (0.69) | NPC1RAB9ATP53HTTKDM4E | |
| SCHEMBL703934 | 0.78 | NPC1 (0.67) | NPC1RAB9ATP53HTTKDM4E | |
| SCHEMBL29267694 | 0.78 | NPC1 (0.64) | NPC1RAB9ATP53HTTKDM4E | |
| SCHEMBL30263346 | 0.78 | PDE5A (0.64) | NPC1RAB9AHTTKDM4EALDH1A1 | |
| SCHEMBL2696505 | 0.77 | NPC1 (0.66) | NPC1RAB9ATP53HTTKDM4E | |
| SCHEMBL27813863 | 0.77 | NPC1 (0.62) | NPC1RAB9ATP53HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220288037-A1 | PRODRUGS AND FORMULATIONS THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-09-15 | — | — | US | claimed |
| CN-114599365-A | Prodrugs and formulations thereof | 内布拉斯加大学董事会 | 2022-06-07 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220288037-A1 | PRODRUGS AND FORMULATIONS THEREOF | UGT1A1, UGT2B7, UGT1A4 | NPC1 259/4885RAB9A 2567/4885TP53 958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.