Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2S1 | P05198 | 2/20 | 0.55 |
| ▸ | EIF2AK3 | Q9NZJ5 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 2/20 | 0.42 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23043953 | 1.00 | EIF2S1 (0.55) | EIF2S1EIF2AK3ALDH1A1LMNAMAPT | |
| SCHEMBL23043869 | 1.00 | EIF2S1 (0.55) | EIF2S1EIF2AK3ALDH1A1LMNAMAPT | |
| SCHEMBL30060949 | 1.00 | EIF2S1 (0.55) | EIF2S1EIF2AK3ALDH1A1LMNAMAPT | |
| SCHEMBL23043868 | 1.00 | EIF2S1 (0.55) | EIF2S1EIF2AK3ALDH1A1LMNAMAPT | |
| SCHEMBL29684110 | 1.00 | EIF2S1 (0.55) | EIF2S1EIF2AK3ALDH1A1LMNAMAPT | |
| SCHEMBL23044625 | 0.89 | EIF2AK3 (0.53) | EIF2S1EIF2AK3FLT3METAXL | |
| SCHEMBL23044033 | 0.89 | EIF2AK3 (0.53) | EIF2S1EIF2AK3FLT3METAXL | |
| SCHEMBL23043897 | 0.89 | EIF2AK3 (0.53) | EIF2S1EIF2AK3FLT3METAXL | |
| SCHEMBL23044035 | 0.89 | EIF2AK3 (0.53) | EIF2S1EIF2AK3FLT3METAXL | |
| SCHEMBL23044036 | 0.89 | EIF2AK3 (0.53) | EIF2S1EIF2AK3FLT3METAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4021908-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | Hibercell, Inc. (US) | 2022-07-06 | — | — | EP | claimed |
| CN-114710956-A | PERK-INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | 希伯塞尔股份有限公司 | 2022-07-05 | — | — | CN | claimed |
| EP-4021908-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | Hibercell, Inc. (US) | 2022-07-06 | — | — | EP | disclosed |
| CN-114710956-A | PERK-INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | 希伯塞尔股份有限公司 | 2022-07-05 | — | — | CN | disclosed |