SCHEMBL29688149

SCHEMBL29688149

CCc1cccc([C@@H](O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(CC)c2)c1

nearest known ligand 0.86

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EIF2AK3 Q9NZJ5 19/20 0.86
EIF2S1 P05198 19/20 0.86

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23044333 1.00 EIF2AK3 (0.86) EIF2AK3EIF2S1
SCHEMBL23044132 1.00 EIF2AK3 (0.86) EIF2AK3EIF2S1
SCHEMBL29687639 1.00 EIF2AK3 (0.86) EIF2AK3EIF2S1
SCHEMBL23044447 1.00 EIF2AK3 (0.86) EIF2AK3EIF2S1
SCHEMBL29688003 1.00 EIF2AK3 (0.86) EIF2AK3EIF2S1
SCHEMBL23044270 0.92 EIF2AK3 (1.00) EIF2AK3EIF2S1
SCHEMBL23044176 0.92 EIF2AK3 (0.85) EIF2AK3EIF2S1
SCHEMBL23044273 0.92 EIF2AK3 (1.00) EIF2AK3EIF2S1
SCHEMBL23044540 0.92 EIF2AK3 (0.85) EIF2AK3EIF2S1
SCHEMBL23044653 0.92 EIF2AK3 (0.85) EIF2AK3EIF2S1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114585606-A PERK inhibiting compounds 希伯塞尔股份有限公司 2022-06-03 CN claimed
EP-4021893-A1 PERK INHIBITING COMPOUNDS Hibercell, Inc. (US) 2022-07-06 EP disclosed
CN-114585606-A PERK inhibiting compounds 希伯塞尔股份有限公司 2022-06-03 CN disclosed