Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 4/20 | 0.59 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26980589 | 1.00 | MRGPRX1 (0.59) | MRGPRX1LIMK1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL26978352 | 0.89 | SMN1; SMN2 (0.51) | MRGPRX1SMN1; SMN2MAPTKMT2AHTT | |
| SCHEMBL26978570 | 0.87 | MRGPRX1 (0.47) | MRGPRX1LIMK1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL29688974 | 0.87 | MRGPRX1 (0.47) | MRGPRX1LIMK1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL26978426 | 0.86 | MRGPRX1 (0.62) | MRGPRX1SMN1; SMN2MAPTKMT2AHTT | |
| SCHEMBL29688985 | 0.86 | MRGPRX1 (0.62) | MRGPRX1SMN1; SMN2MAPTKMT2AHTT | |
| SCHEMBL30700902 | 0.84 | MRGPRX1 (0.50) | MRGPRX1SMN1; SMN2MAPTKMT2AHTT | |
| SCHEMBL26978261 | 0.84 | MRGPRX1 (0.50) | MRGPRX1SMN1; SMN2MAPTKMT2AHTT | |
| SCHEMBL29689513 | 0.83 | MRGPRX1 (0.59) | MRGPRX1LIMK1SMN1; SMN2KMT2AHTT | |
| SCHEMBL26978324 | 0.83 | MRGPRX1 (0.59) | MRGPRX1LIMK1SMN1; SMN2KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4255893-A1 | COMPOUNDS AND THEIR USE FOR TREATING NEUROPATHIC PAIN | The Johns Hopkins University (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022119823-A1 | COMPOUNDS AND THEIR USE FOR TREATING NEUROPATHIC PAIN | THE JOHNS HOPKINS UNIVERSITY (US) | 2022-06-09 | — | — | WO | disclosed |