Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | HPGD | P15428 | 1/20 | 0.74 |
| ▸ | UBE2N | P61088 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | TEK | Q02763 | 9/20 | 0.65 |
| ▸ | KDR | P35968 | 6/20 | 0.65 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.58 |
| ▸ | CDK1 | P06493 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14020859 | 1.00 | KDM4E (0.74) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL2976986 | 0.88 | TNK2 (0.68) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL13271833 | 0.86 | KDM4E (0.76) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL14923113 | 0.85 | KDM4E (1.00) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL1785974 | 0.85 | KDM4E (0.74) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL12355051 | 0.85 | KDM4E (1.00) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL2975999 | 0.85 | KDM4E (0.74) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL14923114 | 0.83 | KDM4E (0.71) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4530280 | 0.82 | KDM4E (0.67) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL14463690 | 0.82 | KDM4E (0.63) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776867-B2 | Furanopyrimidines | AMGEN INC. (US) | 2010-08-17 | — | — | US | disclosed |
| EP-1768986-A2 | FURANOPYRIMIDINES | Amgen Inc. (US) | 2007-04-04 | — | — | EP | disclosed |
| US-20060040961-A1 | Furanopyrimidines | AMGEN INC. | 2006-02-23 | — | — | US | disclosed |
| WO-2006004658-A2 | FURANOPYRIMIDINES | AMGEN INC. (US) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040961-A1 | Furanopyrimidines | TYMS, IDO1, NFATC1 | KDM4E 3284/4885ALDH1A1 159/4885HPGD 1536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.