Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.62 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22570894 | 1.00 | NR1H4 (0.62) | NR1H4HSD17B13 | |
| SCHEMBL29692040 | 0.97 | NR1H4 (0.61) | NR1H4HSD17B13 | |
| SCHEMBL24599006 | 0.97 | NR1H4 (0.61) | NR1H4HSD17B13 | |
| SCHEMBL24599003 | 0.89 | NR1H4 (0.64) | NR1H4HSD17B13 | |
| SCHEMBL29692072 | 0.89 | NR1H4 (0.64) | NR1H4HSD17B13 | |
| SCHEMBL22570943 | 0.89 | NR1H4 (0.59) | NR1H4HSD17B13 | |
| SCHEMBL22570888 | 0.89 | NR1H4 (0.59) | NR1H4 | |
| SCHEMBL29692052 | 0.89 | NR1H4 (0.61) | NR1H4HSD17B13 | |
| SCHEMBL22570928 | 0.89 | NR1H4 (0.61) | NR1H4HSD17B13 | |
| SCHEMBL22570924 | 0.88 | NR1H4 (0.58) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4271377-A1 | COMPOUNDS AND METHODS FOR MODULATING FXR | Terns Pharmaceuticals, Inc. (US) | 2023-11-08 | — | — | EP | disclosed |
| CN-116887827-A | Compounds and methods for modulating FXR | 拓臻制药公司 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022147448-A1 | COMPOUNDS AND METHODS FOR MODULATING FXR | TERNS PHARMACEUTICALS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |