Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6036806 | 1.00 | MEN1 (0.54) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL13226707 | 1.00 | MEN1 (0.54) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL12884775 | 1.00 | MEN1 (0.54) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL28139819 | 1.00 | MEN1 (0.54) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL11892069 | 1.00 | MEN1 (0.54) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL22266203 | 1.00 | MEN1 (0.54) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL10412336 | 1.00 | MEN1 (0.54) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL8928047 | 1.00 | MEN1 (0.54) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL4400006 | 0.97 | MEN1 (0.50) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL11149284 | 0.97 | MEN1 (0.50) | MEN1KMT2ATHRBHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116249787-A | Treatment of obesity with inhibitors of G protein-coupled receptor 75 (GPR 75) | 雷杰纳荣制药公司 | 2023-06-09 | — | — | CN | disclosed |
| EP-4168548-A1 | TREATMENT OF OBESITY WITH G-PROTEIN COUPLED RECEPTOR 75 (GPR75) INHIBITORS | REGENERON PHARMACEUTICALS, INC. (US) | 2023-04-26 | — | — | EP | disclosed |
| US-20220411870-A1 | Treatment Of Obesity With G-Protein Coupled Receptor 75 (GPR75) Inhibitors | REGENERON PHARMACEUTICALS, INC. | 2022-12-29 | — | — | US | disclosed |
| US-11359246-B2 | Treatment of obesity with G-protein coupled receptor 75 (GPR75) inhibitors | REGENERON PHARMACEUTICALS, INC. (US) | 2022-06-14 | — | — | US | disclosed |