Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 13/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | PDE8B | O95263 | 6/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2196841 | 1.00 | TLR7 (0.43) | TLR7TLR8ADORA2AADORA2BPDE8B | |
| SCHEMBL2197219 | 1.00 | TLR7 (0.43) | TLR7TLR8ADORA2AADORA2BPDE8B | |
| SCHEMBL567253 | 1.00 | TLR7 (0.43) | TLR7TLR8ADORA2AADORA2BPDE8B | |
| SCHEMBL1865662 | 0.94 | TLR7 (0.41) | TLR7TLR8ADORA2AADORA2BPDE8B | |
| SCHEMBL565898 | 0.94 | TLR7 (0.41) | TLR7TLR8ADORA2AADORA2BPDE8B | |
| SCHEMBL565909 | 0.92 | ADORA2A (0.41) | TLR7TLR8ADORA2AADORA2BPDE8B | |
| SCHEMBL20261718 | 0.92 | ADORA2A (0.41) | TLR7TLR8ADORA2AADORA2BPDE8B | |
| SCHEMBL2195426 | 0.89 | TLR7 (0.37) | TLR7TLR8ADORA2AADORA2BPDE8B | |
| SCHEMBL20701954 | 0.88 | ADORA2A (0.36) | TLR7ADORA2AADORA2BPDE8B | |
| SCHEMBL565826 | 0.88 | ADORA2A (0.36) | TLR7ADORA2AADORA2BPDE8B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218377-B1 | ADENINE DERIVATIVES WHICH ARE USEFUL IN THE TREATMENT OF ALLERGIC DISEASES OR OTHER INFLAMMATORY CONDITIONS | GLAXOSMITHKLINE BIOLOGICALS SA (BE) | 2022-04-13 | — | — | EP | disclosed |