Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29390828 | 1.00 | ESR2 (0.49) | ESR2NR1H2ADORA1MAPK1HPGDS | |
| SCHEMBL22993469 | 1.00 | ESR2 (0.49) | ESR2NR1H2ADORA1MAPK1HPGDS | |
| SCHEMBL29388325 | 0.89 | ESR2 (0.50) | ESR2NR1H2ADORA1MAPK1HPGDS | |
| SCHEMBL22993235 | 0.89 | ESR2 (0.50) | ESR2NR1H2ADORA1MAPK1HPGDS | |
| SCHEMBL29586561 | 0.83 | ESR2 (0.51) | ESR2NR1H2ADORA1MAPK1HPGDS | |
| SCHEMBL21326104 | 0.83 | ESR2 (0.51) | ESR2NR1H2ADORA1MAPK1HPGDS | |
| SCHEMBL22993465 | 0.82 | ESR2 (0.52) | ESR2NR1H2ADORA1MAPK1HPGDS | |
| SCHEMBL29391249 | 0.82 | ESR2 (0.52) | ESR2NR1H2ADORA1MAPK1HPGDS | |
| SCHEMBL22981751 | 0.81 | BTK (0.34) | ESR2 | |
| SCHEMBL22993240 | 0.81 | ESR2 (0.51) | ESR2NR1H2ADORA1MAPK1HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010333-A1 | PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2022-06-15 | — | — | EP | disclosed |