Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 9/20 | 0.56 |
| ▸ | PARP11 | Q9NR21 | 6/20 | 0.56 |
| ▸ | PARP1 | P09874 | 8/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22982047 | 1.00 | PARP10 (0.56) | PARP10PARP11PARP1CDC7ACHE | |
| SCHEMBL24147834 | 0.82 | CLK4 (0.53) | PARP10PARP11PARP1CDC7MAP2K1 | |
| SCHEMBL30197872 | 0.79 | PARP10 (0.56) | PARP10PARP11PARP1ACHERAF1 | |
| SCHEMBL29144293 | 0.79 | PARP10 (0.56) | PARP10PARP11PARP1ACHEPDPK1 | |
| SCHEMBL29698302 | 0.79 | PARP10 (0.56) | PARP10PARP11PARP1ACHERAF1 | |
| SCHEMBL23951998 | 0.79 | PARP10 (0.56) | PARP10PARP11PARP1ACHERAF1 | |
| SCHEMBL23952300 | 0.79 | PARP10 (0.56) | PARP10PARP11PARP1ACHERAF1 | |
| SCHEMBL24886285 | 0.79 | PARP10 (0.56) | PARP10PARP11PARP1ACHERAF1 | |
| SCHEMBL22990298 | 0.79 | PARP10 (0.56) | PARP10PARP11PARP1ACHERAF1 | |
| SCHEMBL30019767 | 0.79 | PARP10 (0.56) | PARP10PARP11PARP1ACHEPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117242073-A | PRMT5 inhibitors and uses thereof | 海思科医药集团股份有限公司 | 2023-12-15 | — | — | CN | disclosed |
| WO-2022206964-A1 | PRMT5 INHIBITOR AND USE THEREOF | 海思科医药集团股份有限公司 | 2022-10-06 | — | — | WO | disclosed |
| EP-4010334-A1 | HETEROCYCLIC WDR5 INHIBITORS AS ANTI-CANCER COMPOUNDS | Novartis AG (CH) | 2022-06-15 | — | — | EP | disclosed |