Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 6/20 | 0.43 |
| ▸ | CTSG | P08311 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PTPRB | P23467 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | CASP2 | P42575 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | CTRC | Q99895 | 1/20 | 0.36 |
| ▸ | BID | P55957 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL166776 | 1.00 | ELANE (0.43) | ELANECTSGKDM4EALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL27668518 | 0.98 | ELANE (0.43) | ELANECTSGKDM4EALDH1A1GAA | |
| SCHEMBL2508510 | 0.95 | NR1H2 (0.47) | ELANECTSGKDM4EALDH1A1GAA | |
| SCHEMBL29699286 | 0.95 | NR1H2 (0.47) | ELANECTSGKDM4EALDH1A1GAA | |
| Bicarbonate SCHEMBL29212760 | 0.94 | KDM4E (0.46) | ELANECTSGKDM4EALDH1A1GAA | |
| SCHEMBL10725524 | 0.94 | NR1H2 (0.49) | ELANECTSGKDM4EALDH1A1GAA | |
| SCHEMBL8684492 | 0.94 | NR1H2 (0.49) | ELANECTSGKDM4EALDH1A1GAA | |
| SCHEMBL10730459 | 0.94 | NR1H2 (0.49) | ELANECTSGKDM4EALDH1A1GAA | |
| SCHEMBL10725242 | 0.94 | NR1H2 (0.49) | ELANECTSGKDM4EALDH1A1GAA | |
| SCHEMBL9402093 | 0.94 | NR1H2 (0.49) | ELANECTSGKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113527179-B | Chain hydrocarbon substituted isoindoline-1, 3-diketone PDE4 inhibitor and pharmaceutical application thereof | 苏州璞正医药有限公司 | 2023-07-07 | — | — | CN | disclosed |
| WO-2023015944-A1 | SUBSTITUTED ISOINDOLIN-1,3-DIONE PDE4 INHIBITOR AND PHARMACEUTICAL USE THEREOF | 苏州璞正医药有限公司 | 2023-02-16 | — | — | WO | disclosed |
| CN-114790164-B | Substituted isoindoline-1,3-diketone PDE4 inhibitor and pharmaceutical application thereof | 苏州璞正医药有限公司 | 2022-12-27 | — | — | CN | disclosed |
| CN-114790164-A | Substituted isoindoline-1, 3-diketone PDE4 inhibitor and pharmaceutical application thereof | 苏州璞正医药有限公司 | 2022-07-26 | — | — | CN | disclosed |