Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.49 |
| ▸ | ELANE | P08246 | 5/20 | 0.46 |
| ▸ | CTSG | P08311 | 2/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | BID | P55957 | 3/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.43 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.43 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29699197 | 1.00 | NR1H2 (0.49) | NR1H2NR1H3ELANECTSGGPR84 | |
| SCHEMBL29699310 | 1.00 | NR1H2 (0.49) | NR1H2NR1H3ELANECTSGGPR84 | |
| SCHEMBL10725524 | 1.00 | NR1H2 (0.49) | NR1H2NR1H3ELANECTSGGPR84 | |
| SCHEMBL29699171 | 1.00 | NR1H2 (0.49) | NR1H2NR1H3ELANECTSGGPR84 | |
| SCHEMBL10730459 | 1.00 | NR1H2 (0.49) | NR1H2NR1H3ELANECTSGGPR84 | |
| SCHEMBL8684492 | 1.00 | NR1H2 (0.49) | NR1H2NR1H3ELANECTSGGPR84 | |
| SCHEMBL9402093 | 1.00 | NR1H2 (0.49) | NR1H2NR1H3ELANECTSGGPR84 | |
| SCHEMBL29699236 | 1.00 | NR1H2 (0.49) | NR1H2NR1H3ELANECTSGGPR84 | |
| SCHEMBL10725242 | 1.00 | NR1H2 (0.49) | NR1H2NR1H3ELANECTSGGPR84 | |
| SCHEMBL10727262 | 1.00 | NR1H2 (0.49) | NR1H2NR1H3ELANECTSGGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113527179-B | Chain hydrocarbon substituted isoindoline-1, 3-diketone PDE4 inhibitor and pharmaceutical application thereof | 苏州璞正医药有限公司 | 2023-07-07 | — | — | CN | disclosed |
| WO-2023015944-A1 | SUBSTITUTED ISOINDOLIN-1,3-DIONE PDE4 INHIBITOR AND PHARMACEUTICAL USE THEREOF | 苏州璞正医药有限公司 | 2023-02-16 | — | — | WO | disclosed |
| CN-114790164-B | Substituted isoindoline-1,3-diketone PDE4 inhibitor and pharmaceutical application thereof | 苏州璞正医药有限公司 | 2022-12-27 | — | — | CN | disclosed |
| CN-114790164-A | Substituted isoindoline-1, 3-diketone PDE4 inhibitor and pharmaceutical application thereof | 苏州璞正医药有限公司 | 2022-07-26 | — | — | CN | disclosed |