Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 11/20 | 0.38 |
| ▸ | PLAU | P00749 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372260 | 1.00 | CFTR (0.38) | CFTRPLAUHSD17B10KDM4EALDH1A1 | |
| SCHEMBL14816567 | 0.86 | PLAU (0.41) | CFTRPLAU | |
| SCHEMBL2371668 | 0.85 | PLAU (0.36) | CFTRPLAUHSD17B10KDM4EALDH1A1 | |
| SCHEMBL14784270 | 0.81 | CFTR (0.42) | CFTRPLAUKDM4EALDH1A1 | |
| SCHEMBL14783292 | 0.79 | TDP1 (0.46) | PLAUHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL2371732 | 0.78 | KDM4E (0.50) | KDM4EALDH1A1HPGDHTT | |
| SCHEMBL30206229 | 0.78 | KDM4E (0.50) | KDM4EALDH1A1HPGDHTT | |
| SCHEMBL14891402 | 0.77 | PLAU (0.58) | PLAUHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL17628560 | 0.77 | PLAU (0.44) | CFTRPLAUKDM4EALDH1A1TDP1 | |
| SCHEMBL14783203 | 0.75 | CFTR (0.33) | CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3980121-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF, COPD, AND BRONCHIECTASIS | Novartis AG (CH) | 2022-04-13 | — | — | EP | disclosed |